Microbiota derived D-malate inhibits skeletal muscle growth and angiogenesis during aging via acetylation of Cyclin A.

Metabolites derived from the intestinal microbiota play an important role in maintaining skeletal muscle growth, function, and metabolism. Here, we found that D-malate (DMA) is produced by mouse intestinal microorganisms and its levels increase during aging. Moreover, we observed that dietary supplementation of 2% DMA inhibits metabolism in mice, resulting in reduced muscle mass, strength, and the number of blood vessels, as well as the skeletal muscle fiber type I/IIb ratio. In vitro assays demonstrate that DMA decreases the proliferation of vascular endothelial cells and suppresses the formation of blood vessels. In vivo, we further demonstrated that boosting angiogenesis by muscular VEGFB injection rescues the inhibitory effects of D-malate on muscle mass and fiber area. By transcriptomics analysis, we identified that the mechanism underlying the effects of DMA depends on the elevated intracellular acetyl-CoA content and increased Cyclin A acetylation rather than redox balance. This study reveals a novel mechanism by which gut microbes impair muscle angiogenesis and may provide a therapeutic target for skeletal muscle dysfunction in cancer or aging.

Enhancing photocatalytic destruction of lignin via cellulose derived carbon quantum dots/g-C3N4 heterojunctions.

Lignocellulosic biomass exhibits a promising potential for production of carbon materials. Nitrogen and phosphorus co-doped carbon quantum dots (N,P-CQDs) were fabricated via (NH4)2HPO4 assisted hydrothermal treatment of cellulose pulp fibers. The as-prepared N,P-CQDs were characterized by HRTEM, FTIR, fluorescence and UV-vis, and then incorporated into g-C3N4 (CN) through sonication and liquid deposition, forming N,P-CQDs/sonication treated g-C3N4 (C-SCN) composites, which were then explored as photocatalysts. The photocatalytic ability of C-SCN towards model lignin was further analyzed. The results showed that, the fluorescence intensity and photoluminescence performance of N,P-CQDs were much higher than that of CQDs; the heterojunction was successfully constructed between the composites of N,P-CQDs and SCN; the incorporation of N,P-CQDs enhanced the visible light absorption, but reduced the band gap of the composite heterojunction; the resultant photocatalysts exhibited a good photocatalytic ability of model lignin via catalyze the fracture of ß-O-4' ether bond and CC bond, i.e., the photocatalytic degradation ratio reached up to 95.5 %; and the photocatalytic reaction generated some valuable organics such as phenyl formate, benzaldehyde, and benzoic acid. This study would promote the high value-added utilization of lignocellulosic resources especially in the transformation of lignin, conforming the concept of sustainable development.

Upgrading lignin macromolecular by green and recyclable ternary deep eutectic solvents.

Lignin is the most abundant natural aromatic macromolecule in the nature, but its high value-added utilization has been seriously hindered by the highly random and branched structures and the high difficulty in separation and purification. A microwave-assisted ternary deep eutectic solvent (DES) composed by formic acid, lactic acid and choline chloride was developed for lignin pretreatment. The effects of three types of DES on main characteristics of lignin were investigated, and the corresponding dissolution mechanism was proposed. The results showed that, the microwave-assisted ternary DES pretreatment showed an obvious improvement on main characteristics of regenerated lignin, e.g., a higher purity, lower molecular weight with reduced dispersity, improved thermal stability, higher phenolic hydroxyl content, and increased antioxidative activity in comparison with control. It is expected that the lignin macromolecular can be facile regulated and upgraded by the proposed ternary DES.

Switchable broadband/narrowband absorber based on a hybrid metasurface of graphene and metal structures.

This paper proposes a switchable broadband/narrowband absorber based on a hybrid metasurface comprising graphene and metal in the millimeter-wave regime. The designed absorber achieves broadband absorption when the surface resistivity of graphene Rs = 450 Ω/◻ and narrowband absorption when Rs = 1300 Ω/◻ and 2000 Ω/◻. The physical mechanism behind the graphene absorber is explored by analyzing the distributions of power loss, electric field, and surface current densities. An equivalent circuit model (ECM) based on transmission-line theory is derived to theoretically investigate the performance of the absorber, with ECM results in good agreement with simulation results. Furthermore, we fabricate a prototype and evaluate its reflectivity by applying various biasing voltages. The results obtained from the experiment are also consistent with those obtained from the simulation. When the external bias voltage is changed from +1.4 V to -3.2 V, the proposed absorber has an average reflectivity ranging from -5 dB to -33 dB. The proposed absorber has potential applications in radar cross-section (RCS) reduction, antenna design, electromagnetic interference (EMI) shielding, and EM camouflage techniques.

Broadband electrically tunable linear polarization converter based on a graphene metasurface.

In this study, a broadband tunable reflective graphene-based linear polarization converter (GLPC) is proposed based on the graphene-ionic liquid-ITO structure (GIIS) integrated with a periodic double split ring resonator (DSRR) in the millimeter-wave regime. The tuning characteristic of the designed GLPC is analyzed using full-wave simulations and the equivalent circuit model method (ECM), which is based on multi-section transmission lines. There is a good agreement between ECM and simulation results. A comprehensive physical mechanism for the proposed broadband GLPC is then achieved by analyzing the surface current distributions. After manufacturing, the GLPC prototype's co- and cross-polarized reflection coefficients were measured using various bias voltages. The reflectivity can be controlled from -4.5 to -20 dB by changing the bias voltage in the range of +1.1 to -3.3 V. The designed GLPC can provide a tunable polarization conversion within the frequency range of 15.5∼35 GHz and shows a more than 75% conversion efficiency. The results of the simulation and the measurement are also in good agreement. The designed GLPC has potential applications in radar cross-section reduction, antenna design, and stealth technology by reconfiguring its polarized reflection characteristic dynamically.

α-Ketoglutaric acid ameliorates hyperglycemia in diabetes by inhibiting hepatic gluconeogenesis via serpina1e signaling.

Previously, we found that α-ketoglutaric acid (AKG) stimulates muscle hypertrophy and fat loss through 2-oxoglutarate receptor 1 (OXGR1). Here, we demonstrated the beneficial effects of AKG on glucose homeostasis in a diet-induced obesity (DIO) mouse model, which are independent of OXGR1. We also showed that AKG effectively decreased blood glucose and hepatic gluconeogenesis in DIO mice. By using transcriptomic and liver-specific serpina1e deletion mouse model, we further demonstrated that liver serpina1e is required for the inhibitory effects of AKG on hepatic gluconeogenesis. Mechanistically, we supported that extracellular AKG binds with a purinergic receptor, P2RX4, to initiate the solute carrier family 25 member 11 (SLC25A11)-dependent nucleus translocation of intracellular AKG and subsequently induces demethylation of lysine 27 on histone 3 (H3K27) in the seprina1e promoter region to decrease hepatic gluconeogenesis. Collectively, these findings reveal an unexpected mechanism for control of hepatic gluconeogenesis using circulating AKG as a signal molecule.

"Stickier"-Surface Sb2Te3 Templates Enable Fast Memory Switching of Phase Change Material GeSb2Te4 with Growth-Dominated Crystallization.

Ge-Sb-Te (GST)-based phase-change memory (PCM) excels in the switching performance but remains insufficient of the operating speed to replace cache memory (the fastest memory in a computer). In this work, a novel approach using Sb2Te3 templates is proposed to boost the crystallization speed of GST by five times faster. This is because such a GST/Sb2Te3 heterostructure changes the crystallizing mode of GST from the nucleation-dominated to the faster growth-dominated one, as confirmed by high-resolution transmission electron microscopy, which captures the interface-induced epitaxial growth of GST on Sb2Te3 templates in devices. Ab initio molecular dynamic simulations reveal that Sb2Te3 templates can render GST sublayers faster crystallization speed because Sb2Te3's "sticky" surface contains lots of unpaired electrons that may attract Ge atoms with less antibonding interactions. Our work not only proposes a template-assisted PCM with fast speed but also uncovers the hidden mechanism of Sb2Te3's sticky surface, which can be used for future material selection.